PUBLICATIONS

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Successful elimination of bilirubin in critically ill patients with acute liver dysfunction using a cytokine adsorber and albumin dialysis: a pilot study
Sci Rep. 2021 May 13;11(1):10190. doi: 10.1038/s41598-021-89712-4.
C. Scharf, U. Liebchen, M. Paal, A. Becker-Pennrich, M. Irlbeck, M. Zoller, I. Schroeder
https://www.nature.com/articles/s41598-021-89712-4
Applicability and safety of discontinuous ADVanced Organ Support (ADVOS) in the treatment of patients with acute-on-chronic liver failure (ACLF) outside of intensive care
PLoS One. 2021 Apr 1;16(4):e0249342. doi: 10.1371/journal.pone.0249342. eCollection 2021.
L. Kaps, C. J. Ahlbrand, R. Gadban, M. Nagel, C. Labenz, P. Klimpke, S. Holtz, S. Boedecker, M. Michel, W. M. Kremer, M. Hilscher, P. R. Galle, D. Kraus, J. M. Schattenberg, J. Weinmann-Menke
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249342
Registry on extracorporeal multiple organ support with the advanced organ support (ADVOS) system: 2-year interim analysis
Medicine (Baltimore). 2021 Feb 19;100(7):e24653.
V. Fuhrmann, A. Perez Ruiz de Garibay, A. Faltlhauser, B. Tyczynski, D. Jarczak, J. Lutz, J. Weinmann-Menke, A. Kribben, S. Kluge
https://journals.lww.com/md-journal/Fulltext/2021/02190/Registry_on_extracorporeal_multiple_organ_support.40.aspx
Extracorporeal multiorgan support including CO2-removal with the ADVanced Organ Support (ADVOS) system for COVID-19: A case report
The International Journal of Artificial Organs (2020). doi: 10.1177/0391398820961781
W. Huber, G. Lorenz, M. Heilmaier, K. Böttcher, P. Sahm, M. Middelhoff, B. Ritzer, D. Schulz, E. Bekka, F. Hesse, A. Poszler, F. Geisler, C. Spinner, R. M. Schmid, T. Lahmer
https://journals.sagepub.com/doi/full/10.1177/0391398820961781
Advanced organ support (ADVOS) in the critically ill: first clinical experience in patients with multiple organ failure
Annals of Intensive Care volume 10, Article number: 96 (2020).
V. Fuhrmann, T. Weber, K. Roedl, J. Motaabbed, A. Tariparast, D. Jarczak, A. Perez, J. Kluwe, O. Boenisch, H. Herkner, J. Kellum, S. Kluge
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00714-3
Comparison of the albumin dialysis devices Molecular Adsorbent Recirculating System and ADVanced Organ Support in critically ill patients with liver failure ‐ a retrospective analysis
Ther Apher Dial, 2020. Accepted Author Manuscript. doi:10.1111/1744-9987.13533
C. Falkensteiner, A. Kortgen, J. Leonhardt, M. Bauer, C, Sponholz
https://onlinelibrary.wiley.com/doi/abs/10.1111/1744-9987.13533
P254 A non-interventional, multicenter, non-randomized patient registry for multiple organ dialysis with the advos system: 2-year interim analysis in 118 patients
Crit Care, 2020 Mar 24; 24 (Suppl 1): 87
V. Fuhrmann, A. Perez, A. Faltlhauser, B. Tyczynski, D. Jarczak, J. Lutz, J. Weinmann-Menke, W. Huber, A. Kribben, S. Kluge
https://ccforum.biomedcentral.com/articles/supplements/volume-24-supplement-1
Options in extracorporeal support of multiple organ failure
Medizinische Klinik – Intensivmedizin und Notfallmedizin (2020)
W. Huber, A. Perez
https://link.springer.com/article/10.1007/s00063-020-00658-3
A case report about ADVanced Organ Support (ADVOS) in hypoxic hepatitis
Journal für Anästhesie und Intensivbehandlung (2020-2)
T. König, S. Böhm, A. Perez, K. Bressem, C. Spies, S. Weber-Carstens
http://www.anaesthesie-intensivmedizin.com/
Ein nicht-interventionelles, multizentrisches, nicht-randomisiertes Patientenregister zur Anwendungsbeobachtung bei Multiorgan-Dialyse mit ADVOS: 2-jährige Zwischenanalyse bei 118 Patienten
DIVI 2019 – Abstractbuch
V. Fuhrmann, A. Perez, A. Faltlhauser, B. Tyczynski, D. Jarczak, J. Lutz, J. Weinmann-Menke, W. Huber, A. Kribben, S. Kluge
http://react-profile.org/ebook/DIVI2019_Abstractbuch/
Extrakorporale Leberunterstützung mit ADVanced Organ Support (ADVOS) in Patienten mit Akut-auf-chronischem Leberversagen (ACLV) und Hepatorenalem Syndrom - Erste Ergebnisse aus einer Single Center Studie
DIVI 2019 – Abstractbuch
L. Kaps, C.J. Ahlbrand, R. Gadban, W.M. Kremer, C. Labenz, M. Nagel, P. Ploch, J.U. Marquardt, P.R. Galle, J.M. Schattenberg J., Weinmann-Menke
http://react-profile.org/ebook/DIVI2019_Abstractbuch/
ADVOS - Advanced Organ Support - Evaluierung eines neuartigen Extrakorporalverfahrens zum schnellen natriumbilanzneutralen Ausgleich metabolischer Azidosen
DIVI 2019 – Abstractbuch
A. Faltlhauser, D. Codl, F. Kullmann
http://react-profile.org/ebook/DIVI2019_Abstractbuch/
Respiratory and metabolic acidosis correction with the ADVanced Organ Support system
Intensive Care Medicine Experimentalvolume 7, Article number: 56 (2019). doi: 10.1186/s40635-019-0269-7
Perez Ruiz de Garibay A, Kellum J, Honigschnabel J, Kreymann B
https://icm-experimental.springeropen.com/articles/10.1186/s40635-019-0269-7
Successful therapy of massive risperidone-induced rhabdomyolysis using different dialysis and adsorber devices: A case report
Artif Organs. 2019 May 28. doi: 10.1111/aor.13479
Jarczak D, Kluge S, Fuhrmann V
https://www.ncbi.nlm.nih.gov/pubmed/31140191
Feasibility of ultrafiltration in patients treated with the ADVOS/HepaWash-device under haemodynamic monitoring with transpulmonary thermodilution (TPTD) and pulse contour analysis (PCA): The HAEMADVOS-III-study
Crit Care. 2019 Mar 19;23(Suppl 2):72
Huber W, Leinfelder M, Lahmer T, Batres-Baires G, Rasch S, Schreiber S, Schmid R
https://isicem.esn.eu/posters_listing/see_poster/178/2019/jury
Haemodynamic effects of disconnection from the "advanced organ support" (ADVOS): the HAEMADVOS-II-study evaluating the "retransfusion volume challenge option” (REVOLUTION)
Intensive Care Medicine Experimental 2018 (Suppl 2) :40
Huber W, Leinfelder M, Lahmer T, Herner A, Mayr U, Batres-Baires G, Schreiber S, Häberlein M, Habe nicht L, Schmid R
https://icm-experimental.springeropen.com/articles/10.1186/s40635-018-0201-6
The impact of connection to the extracorporeal circuit on haemodynamics (transpulmonary thermodilution (TPTD) and pulse contour analysis (PCA)) in patients treated with the ADVOS/ HepaWash-device: the HAEMADVOS-I-study
Intensive Care Medicine Experimental 2018 (Suppl 2) :40
Huber W, Leinfelder M, Lahmer T, Herner A, Mayr U, Batres-Baires G, Hartter I, Wiesner J, Schmid R
https://icm-experimental.springeropen.com/articles/10.1186/s40635-018-0201-6
Erfahrungen mit Advanced Organ Support (ADVOS) bei Patienten mit Multiorganversagen
DIVI 2018 – Abstractbuch
Fuhrmann V, Weber T, Roedl K, Tariparast A, Jarckzack D, Kluwe J, Boenisch O, Kluge S
http://react-profile.org/ebook/DIVI_2018_Abstractbuch/61/
ADVOS ahmt die Nierenkompensation des Körpers für die Behandlung der respiratorischen Azidose nach: In-vitro-Demonstration
DIVI 2018 – Abstractbuch
Ruiz de Garibay A, Honigschnabel J, Kreymann B
http://react-profile.org/ebook/DIVI_2018_Abstractbuch/62/
Das ADVOS-System: Albumin-Dialyse-basierter Ansatz zur signifikanten und kontinuierlichen Entfernung von wasserlöslichen und proteingebundenen Toxinen auch bei geringen Blutflüssen
DIVI 2018 – Abstractbuch
Ruiz de Garibay A, Honigschnabel J, Kreymann B
http://react-profile.org/ebook/DIVI_2018_Abstractbuch/63/
ADVOS kehrt die metabolische Azidose um, ohne pCO2 zu erhöhen: Proof of Concept in vitro
DIVI 2016 – Abstractbuch
Ruiz de Garibay A, Ende-Schneider B, Kreymann B
http://react-profile.org/ebook/DIVI_2018_Abstractbuch/64/
The ADVOS Device: Albumin Dialysis Based Approach for Significant and Continuous Removal of Water Soluble and Protein Bound Toxins Even at Low Blood Flows
Blood Purif 2018;46:163–186
Perez Ruiz de Garibay A, Honigschnabel J, Kreymann B
https://www.karger.com/Article/Abstract/490123
ADVOS Reverses Metabolic Acidosis Without Elevating pCO2: Proof of Concept In Vitro
Blood Purif 2018;46:163–186
Perez Ruiz de Garibay A, Ende-Schneider B, Kreymann B
https://www.karger.com/Article/Abstract/490123
ADVOS Corrects Respiratory Acidosis Mimicking the Body’s Renal Compensation: In Vitro Demonstration
Blood Purif 2018;46:163–186
Perez Ruiz de Garibay A, Ende-Schneider B, Kreymann B
https://www.karger.com/Article/Abstract/490123
ADVOS reduces liver and kidney disease markers and corrects acidosis: the Hamburg experience
Critical Care 2018 22(Suppl 1):82
Fuhrmann VH, Jarczak D, Boenisch O, Kluge S
https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-1973-5
Evaluation of an ADVanced Organ Support (ADVOS) system in a two-hit porcine model of liver failure plus endotoxemia
Al-Chalabi A, Matevossian E, von Thaden A, Schreiber C et al.
Intensive Care Med Exp. 2017; 5(1):31
https://icm-experimental.springeropen.com/articles/10.1186/s40635-017-0144-3
First clinical experience in 14 patients treated with ADVOS: a study on feasibility, safety and efficacy of a new type of albumin dialysis
Huber W, Henschel B, Schmid R, Al-Chalabi A
BMC Gastroenterology 2017; 17:23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312588/
Advanced Organ Support (ADVOS) based on albumin dialysis, a new method for CO₂ removal and pH stabilization
Perez Ruiz de Garibay A, Ende-Schneider B, Schreiber C, Kreymann B
Critical Care 2017; 21 (Suppl 1):57
http://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1628-y
Combined removal of 4.5 mol/day of protons and protein bound and water soluble substances in an ex vivo model for metabolic acidosis using an Advanced Organ Support (ADVOS) system based on albumin dialysis
Perez Ruiz de Garibay A, Ende-Schneider B, Schreiber C, Kreymann B
Critical Care 2017; 21 (Suppl 1):58
http://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1629-x
Anwendung eines neuartigen Hämodialyseverfahrens bei einem septischen Patienten mit hyperkapnischem Lungenversagen
Tariparast P, Roedl K, Horvatits T, Drolz A, Jarczak D, Siedler S, Kluge S, Fuhrmann V
Abstractbuch des 16. Kongress der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin; 2016 Nov 30 –Dec 2; Hamburg. Deutschland: DIVI; 2016. Abstract EP/04/10.
http://online-divi.de/img/DIVI/content/abstracts2016.pdf?v=1
Das Advanced Organ Support (ADVOS) Verfahren in der Therapie des Multiorganversagens
Sollinger D, Dörken M, Lutz J
Abstractbuch des 16. Kongress der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin; 2016 Nov 30 –Dec 2; Hamburg. Deutschland: DIVI; 2016. Abstract EP/06/05.
http://online-divi.de/img/DIVI/content/abstracts2016.pdf?v=1
Erste Erfahrungen mit einem neuen erweiterten Dialyseverfahren bei kritisch kranken Patienten mit Multiorganversagen
Fuhrmann V, Drolz A, Horvatits T, Roedl K, Horvatits K, Benten D, Kluwe J, Jarczak D, Tariparast P, Siedler S, Kluge S
Abstractbuch des 16. Kongress der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin; 2016 Nov 30 –Dec 2; Hamburg. Deutschland: DIVI; 2016. Abstract EP/06/10.
http://online-divi.de/img/DIVI/content/abstracts2016.pdf?v=1
Erste Erfahrungen mit dem ADVOS-Verfahren (Advanced Organ Support) bei Patienten mit alkoholischer Steatohepatitis (ASH)
Huber W, Henschel B, Lahmer T, Braun M, Schmid R et al.
Abstractbuch des 16. Kongress der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin; 2016 Nov 30 –Dec 2; Hamburg. Deutschland: DIVI; 2016. Abstract EP/06/12.
http://online-divi.de/img/DIVI/content/abstracts2016.pdf?v=1
Erfolgreiche Therapie einer schwerwiegenden Rhabdomyolyse nach Einnahme von Risperidon durch den Einsatz verschiedener Dialyse- und Adsorptionsverfahren (ADVOS, CVVHD, CytoSorb)
Jarczak D, Wehmeyer M, Roedl K, Tariparast P, Horvatits T, Drolz A, Rutter K, Siedler S, Kluge S, Fuhrmann V
Abstractbuch des 16. Kongress der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin; 2016 Nov 30 –Dec 2; Hamburg. Deutschland: DIVI; 2016. Abstract EP/06/13.
http://online-divi.de/img/DIVI/content/abstracts2016.pdf?v=1
First clinical experience with a new type of albumin dialysis: the Hepa Wash system
Henschel B, Schmid R, Huber W.
Critical Care 2015; 19 (Suppl 1):P383 (16 March 2015)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471673
Fachpflege Nephrologie und Dialyse: Leberunterstützungstherapien
Kreymann B, Riedelsdorf G, Schreiber C, Breuch G, Müller E
5. Aufl. s.l.: Urban Fischer Verlag – Nachschlagewerke; 2014
http://shop.elsevier.de/fachpflege-nephrologie-und-dialyse-9783437262531.html
Evaluation of the Hepa Wash treatment in pigs with acute liver failure
Al-Chalabi A, Matevossian E, v. Thaden A, Luppa P, Neiss A, Schuster T et al.
BMC Gastroenterology 2013; 13(1):83
http://link.springer.com/article/10.1186%2F1471-230X-13-83
Leberunterstützungstherapien 2010: Mehr Fragen als Antworten
Al-Chalabi A, Kreymann B, Huber W
Intensivmedizin und Notfallmedizin. 2010; 47(8):576–81
http://link.springer.com/article/10.1007/s00390-010-0194-1
A model of ischemic isolated acute liver failure in pigs: standardizing monitoring and treatment
Al-Chalabi A, Matevossian E, Preissel A, Perren A, Yang Z et al.
European Surgical Research 2010; 45(2):86–97
http://www.karger.com/Article/Pdf/319878
Improvement of survival in a swine model of acute liver failure by a new liver support system (Hepa Wash)
Al-Chalabi A, Matevossian E, Preissel A, Yang Z, Schreiber C, Schimmel P et al.
Journal of Hepatology 2010; 52:319-320
http://www.journal-of-hepatology.eu/article/S0168-8278%2810%2960820-3/abstract
Survival improvement in pigs with liver failure and superimposed sepsis by a new liver support system (Hepa Wash)
Al-Chalabi A, Matevossian E, Preissel A, Yan H, Geiger A et al.
Critical Care 2010; 14(Suppl 1):P508
http://ccforum.biomedcentral.com/articles/10.1186/cc8740
Möglichkeiten und Zukunftsperspektiven der Leberersatztherapie
Al-Chalabi A, Kreymann B, Langgartner J, Brünnler T
Intensivmedizin und Notfallmedizin 2009; 46(5):347–54
http://link.springer.com/article/10.1007/s00390-009-0039-y
Citrate pharmacokinetics and calcium levels during high-flux dialysis with regional citrate anticoagulation
Kozik-Jaromin J, Nier V, Heemann U, Kreymann B, Böhler J
Nephrology Dialysis Transplantation 2009; 24(7):2244–51
http://www.ncbi.nlm.nih.gov/pubmed/19196824/
Grundlagen der Nieren- und Leberdialyse
Schreiber C, Al-Chalabi A, Tanase O, Kreymann B
In: Wintermantel E, Ha S-W (eds)
Medizintechnik: Life Science Engineering. Springer Berlin/Heidelberg; 2009. P 1519–84
http://www.springerlink.com/content/u544786w0371k285/
Treatment of septic patients with an arginine-based endotoxin adsorber column improves hemodynamics and reduces oxidative stress: results of a feasibility study
Umgelter A, Reindl W, Lutz J, Kreymann B, Ronco C, Huber W et al.
Blood Purif 2008; 26(4):333–9
http://www.ncbi.nlm.nih.gov/pubmed/18483452
Haemodialysis for the prevention of contrast-induced nephropathy: outcome of 31 patients with severely impaired renal function, comparison with patients at similar risk and review
Huber W, Jeschke B, Kreymann B, Hennig M, Page M et al.
Investigative radiology 2002; 37(9):471–81
https://www.ncbi.nlm.nih.gov/pubmed/12218442
Albumin dialysis: effective removal of copper in a patient with fulminant Wilson disease and successful bridging to liver transplantation: a new possibility for the elimination of protein-bound toxins
Kreymann B, Seige M, Schweigart U, Kopp KF, Classen M
Journal of Hepatology 1999; 31(6):1080–5
https://www.ncbi.nlm.nih.gov/pubmed/10604583
Long-term treatment of patients with acute exacerbation of chronic liver failure by albumin dialysis
Seige M, Kreymann B, Jeschke B, Schweigart U, Kopp KF et al.
Transplantation Proceedings 1999; 31(1-2):1371–5
https://www.ncbi.nlm.nih.gov/pubmed/10083608/

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